Medical advancement is based on clinical research, which makes it possible to develop novel cures, treatments, and preventative measures. Ethical challenges in clinical research, however, present significant issues alongside offering hope for innovation. The safety, dignity, and rights of participants must always come first. These ethical issues have grown increasingly complex in today’s environment, where digital technology, international collaboration, and rapidly evolving methodologies are prevalent. Ensuring patient safety, informed consent, and adherence to regulatory guidelines like Good Clinical Practice (GCP) …